How long for Prilosec to kick in ?

[Anonymous]

My 3 month old son was diagnosed with reflux and a milk/soy protein allergy in July. His pedi had put him on zantac .8 mL 2x a day and when we went to the GI in the end of July he he changed his formula from Alimentum to Neocate and upped the zantac to 1 mL 3x a day and he had been doing wonderfully since then. We had a follow up on Wednesday and the GI decided to change him to Prilosec. Its been a little over 24 hours and he is miserable – crying, arching his back and inconsolable. Does anyone have any idea how long it takes for the prilosec to kick in ? The GI said 3-7 days, but I’ve seen 3-7 weeks on different websites and I honestly don’t know if I can handle 3-7 weeks…I am kicking myself right now for agreeing to the medication change

Thanks,
Amy

[Anonymous]

I should of added that he’s on 2.5 mL’s 2x a day of prilosec. The on-call pedi GI suggested giving him 1 mL of Myanta every 6 hours for added relief. He is already getting 1 mL of Mylanta 2x a day to help with the constipation issues from the Neocate and I am hesistent to give him anymore because of the aluminum in it. We tried the Mylanta Supreme before, but he had stomach distress from it so we have to use the regular Mylanta.

[Anonymous]

The reason this is probably happening is that I am guessing they told you to stop the zantac? You can give both! And you should! Just space it 4 hrs apart from the Prilosec. Right now, since prilosec has not kicked in, it’s like your baby isn’t on anything at all! Many of us learned this the hard way.

My boys are med-free now, but if you look at many of the signatures on this website, tons of the moms actually regularly give a PPI drug (like prilosec, prevacid, zegerid) PLUS an H2 blocker like Zantac, Pepcid, etc. My younger son was on a high dose of Prevacid & Pepcid at the same time (just spaced all out) at certain times during reflux!

Good luck, you’ve found an amazing site here. It’s been my lifeline.

jilly782008-08-23 07:51:47

[hellbennt]

prilosec kicked in on day 12 for us.

we learned the HARD WAY that zantac should be used, too.

baby screamed/shrieked so much that he lost his voice. it was PITIFUL!!

so please give that zantac, just space it from the prilosec.

also: please learn about the various forms and doses of PPIS…

if your prilosec is compounded, you MUST REQUEST for it to be done an EXACT way. actually, I’d ask for prevacid in caracream. we did prilosec in caracream and wound up w/ prevacid in caracream. started on pepid, then zantac, then prilosec compounded the wrong way, etc…

read here:

Prevacid 101(last post on the page): https://www.infantreflux.org/forum/forum_posts.asp?TID=1936&PN=0&TPN=1

[Anonymous]

It sounds like you’re on a compound. I personally seriously dislike them, only b/c we had such a bad experience. They’re very hard to get them made correctly. I never could get it done, personally. If your compound if flavoured then it’s definitely not being made correctly. Also, marci-kids swears that as per their research, each dose of compound must be at least 3.5ml to ensure that there’s enough buffer per dose to protect the med. No pharmacist I ever saw knew about this. That being said, when we finally got her on prevacid in CaraCream, things were much better and it was evident that the compound never worked. Unfortunately she had a terrible feeding aversion at that point.

I would look up how to make a compound- I think it’s stickied under the medicine section, about PPIs or about pharmacy compounded PPIs. Ask for a printout of the ingredients that are in your child’s meds, and see how much buffer is in it.

If the med isn’t made properly, then it won’t work. The other problem is that some docs go from zantac to a low dose of PPI. But the PPI dose is too low, so the meds do nothing.

Sorry if this sounds harsh- typing quickly… I’d check out the marci-kids site. They have good info about dosing and administration of PPIs. I’d personally go for CaraCream with prevacid. Prilosec is so hard to give and tastes TERRIBLE relative to the prevacid. Or I’d even try the solutabs… but they’re harder to give and need to be timed around meals. Either way, make sure the dose is high enough.

Good luck.

[Anonymous]

We one the other hand have had a GREAT exp with a compounded Prilosec. You have to get them made a a good pharmacy. Our child. hosp. makes it for us.

Jedd has been on his for aobut 14 months or more. It takes about 2 weeks to kick in. His compounded med has him completely pain free. We took him off meds to see if he reallyneeded them and YES we saw a difference and put him back on.

So that right there tells me we are gettign a good compound. The pharmacy we use litterlaly fills hundreds and hundreds of RX a day. They are extrmely busy every time I am in there. They even handle the ins. co. for us every month.

You can add in a OTC med like Mylanta. Yo uhav eto space th edoses aprat though. I *(think* that mylanta needs to vbegiven at least 30min BEFORE a meal and at least 2 hours after any meal. So it can be tricky.

You also have to space it aobut 2 hours after a med.

I would ask the phamracist about the doseing and spacing becasue they can tell you for certain.

[Anonymous]

As Jessica says, you really need to have communication with a knowledgeable pharmacist. This can be hard to find IMO, in fact I never managed to find it, and we live in a major city.

My advice: ask your pharmacy for the printout of the ingredients and amounts of each ingredient going into your compound. I’d bet that it’s not being made correctly. The fact that he’s only getting 2.5ml per dose is incorrect in and of itself as per the research that marci-kids did on how to make compounds. We went to the most reputable upscale pharmacy in our city. They told me that we most definitely were getting it done correctly and we were not. Even our children’s hospital told us that they won’t make the compounds for PPIs anymore because it’s too hard to get it done correctly and they found it wasn’t very effective as a result.

If you’re going to use the compound, then please read the information on this site that I directed you to before. I’ll try to paste the link, and ask for your compound to made that way. Only problem is that when prilosec suspension is made correctly, it’s almost unpalatable… tastes really bad!

I hope this reply does not sound argumentative. That’s not my intent. But I firmly believe this to be true. My dd was on compounded prilosec from 2-8 months old. She developed an unbelievable feeding aversion because of it as it did not control her pain, and the compounding pharmacy and the compounding pharmacy association who I later complained to said that they were following the outlined standards (which are few) for how to make it. They were giving us 20mg of prilosec in two doses, each of 0.5ml!!! On my travels through cyberspace, I’ve only met a few people who have had good experiences with the compounds. Most are tube fed and don’t have to take the med orally. I don’t know if this makes the difference.

Good luck.

[Anonymous]

Here’s the link. I think I replied in that thread as well, so sorry for the repetition…

https://www.infantreflux.org/forum/forum_posts.asp?TID=4505

[Anonymous]

Thank you for all of the information about compounds and giving zantac while giving the prilosec. I knew that compounds are difficult to make because Josh’s GI won’t use “chain” pharmacies becauses he’s has such issues with them screwing up the compounds so we went to a phramacy 30 minutes away that specializes in compounds. I will call them in the morning and tell them that I am coming down and would like a list of ingredients that are in the compound. I’m at my wits end right now. He screams whenever we give him the prilosec, he arches his back and screams and cries during and after his bottle and he’s now gone from eating 20 ounces a day (which I already thought was low, but he’s gaining weight so they aren’t concerned…) to 12-16 ounces. He’s getting his next dose of Prilosec at nine and I plan on waking him up at one and giving him his zantac and seeing if this helps.

[hellbennt]

you can perhaps skip the compounding issue altogether and go for caracream?

just a thought, as many of us have had great success with it:

Caracream: https://www.infantreflux.org/forum/forum_posts.asp?TID=11191&PID=94236#94236

[Anonymous]

I agree with Laura… in the end, CaraCream was the only answer for us. Even the high end compounding pharmacy here couldn’t get it right.

[Author]

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